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Cell Biol Int. 1996 Dec;20(12):787-97.

Synergistic antitumour activity of vitamins C and K3 against human prostate carcinoma cell lines.

Author information

1
Department of Urology, Summa Health System/Northeastern Ohio Universities College of Medicine, Rootstown 44272, USA.

Abstract

Vitamins C, K3 (VC, VK3) and a VC/VK3 combination with a VC:VK3 ratio of 100:1 were assayed for their antitumour activity against two human prostatic carcinoma cell lines. Co-administration of the vitamins enhanced the antitumour activity 5- to 20-fold even with a 1 h exposure time. While exogenous catalase destroyed the antitumour activity, hydrogen peroxide-induced lipid peroxidation was negligible. Analysis of cellular ATP and thiol levels as well as DNA and protein synthesis revealed: a transient increase in ATP production, a decrease in DNA synthesis, an increase in protein synthesis and a decrease in thiol levels. These results suggested that the increased cytotoxicity of the vitamin combination was due to redox cycling and increased oxidative stress.

PMID:
9032939
DOI:
10.1006/cbir.1996.0102
[Indexed for MEDLINE]

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