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J Virol. 1997 Mar;71(3):2562-6.

Mapping and characterization of the origin of DNA replication of porcine circovirus.

Author information

1
Fachbereich Gentechnik und Genetik, Robert Koch-Institut, Berlin, Germany.

Abstract

The origin of DNA replication of porcine circovirus (PCV) was mapped to a 111-bp fragment. On top of a hairpin, a nonanucleotide (TAGTATTAC) homologous to nonanucleotides of other viruses was identified. Mutation of this element abolishes replication. PCV may be related to a virus family characterized by single-stranded circular DNA genomes, rolling-circle replication, and homology of their rep proteins.

PMID:
9032401
PMCID:
PMC191374
[Indexed for MEDLINE]
Free PMC Article

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