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Curr Opin Struct Biol. 1997 Feb;7(1):126-34.

The role of water in protein-DNA interactions.

Author information

1
Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. jws@sbl.salk.edu

Abstract

It is becoming well accepted that water plays an important role in both the specificity and affinity of protein-DNA interactions. Recently, a combination of structural, biochemical and thermodynamic techniques has particularly enhanced our understanding of the role of water in complexes between DNA and three different proteins: the trp repressor; the homeodomain; and the glucocorticoid receptor DNA-binding domain.

PMID:
9032063
[Indexed for MEDLINE]

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