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Gene. 1997 Jan 15;184(2):197-203.

Analysis of four tylosin biosynthetic genes from the tylLM region of the Streptomyces fradiae genome.

Author information

1
Department of Biochemistry, University of Leicester, UK.

Abstract

The tylLM region of the tylosin biosynthetic gene cluster of Streptomyces fradiae contains four open reading frames (orfs1*-4*). The function of the orf1* product is not known. The product of orf2* (tylM2) is the glycosyltransferase that adds mycaminose to the 5-hydroxyl group of tylactone, the polyketide aglycone of tylosin (Ty). A methyltransferase, responsible for 3-N-methylation during mycaminose production, is encoded by orf3* (tylM1). The product of orf4* (cer) is crotonyl-CoA reductase, which converts acetoacetyl-CoA to butyryl-CoA for use as a 4C extender unit during tylactone production.

PMID:
9031628
DOI:
10.1016/s0378-1119(96)00595-1
[Indexed for MEDLINE]

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