Format

Send to

Choose Destination
Leuk Lymphoma. 1996 Nov;23(5-6):459-65.

Molecular cytogenetics of t(12;21) (p13;q22).

Author information

1
U 301 de l'Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.

Abstract

The translocation t(12;21)(p13;q22) is a frequent nonrandom rearrangement of B-cell lineage childhood acute lymphoblastic leukemia (ALL) which fuses the TEL and AML1 genes, normally localized to 12p13 and 21q22, respectively. The crucial chimeric gene, TEL-AML1, is transcribed from the der(21) and encodes the 336 NH2 aminoacics of TEL fused to the majority of the AML1 protein. The t(12;21) is very often associated with loss of the normal, untranslocated TEL allele. These various aspects are presented here.

PMID:
9031076
DOI:
10.3109/10428199609054854
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center