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Mol Cell Neurosci. 1996;8(4):286-99.

Postsynaptic element contributes to the delay in synaptogenesis in synapsin I-deficient neurons.

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Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.


In a previous study, we reported a retardation in process outgrowth and synapse formation in cultured hippocampal neurons from synapsin I-deficient mice. Here we investigated whether this delay in synaptogenesis was attributable to pre- or postsynaptic elements. The experimental paradigm used in this study involved the establishment of heterochronic cocultures of neurons from wild-type and synapsin I-deficient neurons established synapses with mature wild-type postsynaptic elements after 24 and 72 h, respectively. In contrast, synapsin I-deficient postsynaptic elements were able to receive synapses only after 9 days in culture, representing a 5-day delay compared to controls. The results suggest a broad role of synapsin I in the structural development of the synapse, participating directly or indirectly in the maturation of both presynaptic and postsynaptic sites.

[Indexed for MEDLINE]

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