Send to

Choose Destination
See comment in PubMed Commons below
Aviat Space Environ Med. 1996 Sep;67(9):872-3.

Mefloquine versus doxycycline for malaria prophylaxis in intermittent exposure of Israeli Air Force aircrew in Rwanda.

Author information

  • 1Israeli Air Force Aeromedical Center, Tel Hashomer, Israel.



The issue of the best chemoprophylaxis agent for aircrew to use against malaria is still not settled.


We studied the patterns of use of both doxycycline and mefloquine in aviators and other aircrew for 2 mo during biweekly flights from Israel to Rwanda with a few hours' visits. Some 28 aviators and 15 non-aviator aircrew were treated with doxycycline and mefloquine, respectively, less than 12 h before the first flight and up to 4 wk after the last return.


No case of malaria occurred within or after the operational period. Compliance was better for mefloquine than for doxycyline for the full period of the operation (100% vs. 75%, respectively). The rate of side effects, mostly gastrointestinal, was higher for doxycycline (39% vs. 13%, respectively) and was related mainly to the frequency of administration (daily vs. weekly).


In situations involving frequent intermittent short-term visits to areas with substantial risk of acquiring malaria, we conclude that aircrew can safely take weekly mefloquine as prophylaxis.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center