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Trends Microbiol. 1997 Jan;5(1):37-42.

The bacterial outer membrane as a drug barrier.

Author information

1
Dept of Microbiology and Immunology, University of British Columbia, Vancouver, Canada. bob@cbdn.ca

Abstract

The outer membranes of Gram-negative bacteria constitute a semi-permeable barrier, as indicated by the corresponding alterations in outer membrane permeability and in antibiotic susceptibility resulting from mutation or polycation action. Restricted outer membrane permeability works in synergy with co-determinant resistance mechanisms, such as the periplasmic enzyme beta-lactamase or active efflux mechanisms, bringing about antibiotic resistance.

PMID:
9025234
DOI:
10.1016/S0966-842X(97)81773-8
[Indexed for MEDLINE]

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