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Curr Opin Genet Dev. 1997 Feb;7(1):39-45.

Retinoblastoma protein in growth suppression and death protection.

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Department of Biology, University of California, San Diego 9500 Gilman Drive, La Jolla, California 92093-0347, USA.


Puzzling new information indicates an inadequacy in our understanding of the retinoblastoma protein (RB). RB and the transcription factor E2F appear to be collaborators. RB-E2F interaction is necessary but not sufficient for growth suppression. Unbecoming of a tumor suppressor, RB has an active role in antagonizing the death response. How RB integrates its multiple functions into a tumor suppression program is still an open issue.

[Indexed for MEDLINE]

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