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Curr Opin Genet Dev. 1997 Feb;7(1):93-8.

Control of cell cycle arrest by the Mec1sc/Rad3sp DNA structure checkpoint pathway.

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MRC Cell Mutation Unit, Sussex University, Falmer BN1 9RR UK. a.m.


The Mec1(sc)/Rad3(sp) protein family is central to the checkpoint pathways of cells. Functions upstream and downstream of Mec1(sc)/Rad3(sp) show both similarities and differences when compared between organisms. Analogy with a related protein, DNAPKcs, suggests that different subunits may activate Mec1(sc)/Rad3(sp) in response to specific DNA or DNA-protein structures.

[Indexed for MEDLINE]

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