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Curr Opin Genet Dev. 1997 Feb;7(1):93-8.

Control of cell cycle arrest by the Mec1sc/Rad3sp DNA structure checkpoint pathway.

Author information

1
MRC Cell Mutation Unit, Sussex University, Falmer BN1 9RR UK. a.m. carr@sussex.ac.uk

Abstract

The Mec1(sc)/Rad3(sp) protein family is central to the checkpoint pathways of cells. Functions upstream and downstream of Mec1(sc)/Rad3(sp) show both similarities and differences when compared between organisms. Analogy with a related protein, DNAPKcs, suggests that different subunits may activate Mec1(sc)/Rad3(sp) in response to specific DNA or DNA-protein structures.

PMID:
9024628
[Indexed for MEDLINE]

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