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Curr Opin Genet Dev. 1997 Feb;7(1):99-104.

Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks.

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Division of Molecular Oncology, Departments of Pathology, Biochemistry and Molecular Biophysics, Campus Box 8118, Washington University Schoolof Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA.


A convergence of information from biochemistry, yeast and mammalian genetics, immunology, and radiation biology has permitted identification of some of the protein participants - Ku, DNA-PK, XRCC4 - and the reaction intermediates in DNA end joining, suggesting how broken chromosomal ends may be recognized and repaired in eukaryotic cells. Some components may be defective in inherited disorders.

[Indexed for MEDLINE]

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