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Cytokine Growth Factor Rev. 1996 Dec;7(4):297-302.

Trans-signaling by cytokine and growth factor receptors.

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Department of Cell Biology and Anatomy, Cornell University Medical College, New York, NY 10021, USA.


Although ligand-induced dimerization or oligomerization of receptors is a well established mechanism of growth factor signaling, increasing evidence indicates that biological responses are often mediated by receptor trans-signaling mechanisms involving two or more receptor systems. These include G protein-coupled receptors, cytokine, growth factor and trophic factor receptors. Greater responsiveness and inhibitory signaling responses are provided when different signaling pathways merge through receptor trans-signaling.

[Indexed for MEDLINE]

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