Format

Send to

Choose Destination
Cytokine Growth Factor Rev. 1996 Dec;7(4):297-302.

Trans-signaling by cytokine and growth factor receptors.

Author information

1
Department of Cell Biology and Anatomy, Cornell University Medical College, New York, NY 10021, USA.

Abstract

Although ligand-induced dimerization or oligomerization of receptors is a well established mechanism of growth factor signaling, increasing evidence indicates that biological responses are often mediated by receptor trans-signaling mechanisms involving two or more receptor systems. These include G protein-coupled receptors, cytokine, growth factor and trophic factor receptors. Greater responsiveness and inhibitory signaling responses are provided when different signaling pathways merge through receptor trans-signaling.

PMID:
9023053
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center