Format

Send to

Choose Destination
Fertil Steril. 1997 Feb;67(2):256-60.

Effects of clomiphene citrate on the endometrial thickness and echogenic pattern of the endometrium.

Author information

1
Department of Obstetrics and Gynecology, Yamaguchi University School of Medicine, Japan.

Abstract

OBJECTIVE:

To study the effects of clomiphene citrate (CC) on the endometrium by ultrasound and to reveal the echogenic difference between the control cycle and the CC cycle.

DESIGN:

Retrospective study of patients before and during a CC treatment.

SETTING:

Department of Obstetrics and Gynecology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.

PATIENT(S):

Seventy-nine infertile women who had a spontaneous ovulation and a normal luteal function.

INTERVENTION(S):

Patients received 50 mg/d CC between days 5 and 9 of the menstrual cycle.

MAIN OUTCOME MEASURE(S):

Endometrial thickness, echogenic pattern of the endometrium, serum E2 content, and E2 and P receptor contents in the endometrium.

RESULT(S):

Endometrial thickness was significantly thinner during the CC cycle (7.6 +/- 1.4 mm, mean +/- SD, n = 79) than during the control cycle (8.5 +/- 1.7 mm, n = 79) on late proliferative days, but there was no significant difference on midsecretory days (10.8 +/- 2.2 mm during the CC cycle, n = 79; 11.2 +/- 2.2 mm during the control cycle, n = 79). The echogenic patterns, however, were different between the two cycles on midsecretory days. Moreover, the incidence in which patients showed a grade 3 endometrium on midsecretory days was significantly higher during the conceived CC cycle compared with the not-conceived CC cycle. Serum E2 levels were significantly higher, but E2 receptor contents in the endometrium were significantly lower during the CC cycle (67 +/- 46 fmol/mg, n = 13) compared with the control cycle (123 +/- 89 fmol/mg, n = 15) on late proliferative days.

CONCLUSION(S):

Clomiphene citrate affected the echogenic pattern of the endometrium, and most of the endometrium showed a grade 3 pattern on midsecretory days during the conceived CC cycle. Under the CC treatment, the comfortable endometrium for embryos might be different from the control cycle.

PMID:
9022599
DOI:
10.1016/S0015-0282(97)81907-3
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center