Send to

Choose Destination
See comment in PubMed Commons below
Int J Biochem Cell Biol. 1996 Nov;28(11):1191-5.

NADPH oxidase.

Author information

Department of Medicine, University College London, Rayne Institute, U.K.


Superoxide is instrumental in the killing of microorganisms by phagocytic cells. It is generated by the NADPH oxidase system, a membrane-bound electron transport complex which pumps electrons from NADPH in the cytoplasm across the wall of the phagocytic vacuole to molecular oxygen. Superoxide deficiency results in the genetically inherited condition Chronic Granulomatous Disease (CGD), in which the patient is abnormally susceptible to infection. In recent years many of the underlying genetic defects in CGD have been identified and are providing important insights into the structure and mechanism of the NADPH oxidase complex.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center