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Ophthalmology. 1997 Jan;104(1):33-7.

Perifoveal capillary network in patients with acute central retinal vein occlusion.

Author information

1
Augenklinik der Med. Fakultat. der RWTH Aachen, Germany.

Abstract

PURPOSE:

Reduction of visual acuity in patients with central retinal vein occlusion (CRVO) is often caused by macular edema and ischemia. The major causative factor for macular changes may be a disturbance in the macular microcirculation. The authors studied the perifoveal microcirculation in patients with central retinal vein occlusion to quantify the extent of circulatory deficiency in the macular circulation.

METHODS:

Twenty-four patients (8 men, 16 women) with recently diagnosed CRVO were included in this study. The following data were quantified: mean capillary blood velocity (CBV), foveal avascular zone (FAZ), and mean perifoveal intercapillary area (PIA).

RESULTS:

In patients with CRVO, the mean flow velocity was significantly reduced compared with healthy subjects (1.63 +/- 0.220 mm/sec vs. 2.89 +/- 0.41 mm/sec, P < 0.01). The FAZ and the mean PIA characterizing capillary density were significantly enlarged in CRVO (5548 +/- 1151 microm2 vs. 3872 +/- 529 microm2; P < 0.01).

CONCLUSIONS:

The present study demonstrates that CRVO not only led to a decrease in capillary blood velocities, but also to an enlargement of perifoveal intercapillary areas in early stages of the disease.

PMID:
9022101
DOI:
10.1016/s0161-6420(97)30365-0
[Indexed for MEDLINE]

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