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Trends Biochem Sci. 1997 Jan;22(1):14-7.

RB kinases and RB-binding proteins: new points of view.

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National Cancer Center Research Institute, Tokyo, Japan.


The retinoblastoma protein (RB) binds to a variety of cellular proteins and suppresses cellular growth. Such interactions are regulated by phosphorylation during the cell cycle by several cyclin-dependent kinases, known as RB kinases. Clues to the specific physiological roles of different RB kinases have been obtained. Moreover, interesting functions of the RB protein, other than control of E2F activity, have been found.

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