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Biochem Biophys Res Commun. 1997 Jan 3;230(1):1-6.

Telomere crisis, the driving force in cancer cell evolution.

Author information

1
Department of Life Science, Tokyo Institute of Technology, Midori-ku, Yokohama, Japan.

Abstract

Cancer cells show characteristic telomere dynamics. Their chromosomes usually have short telomeres and a high telomerase activity. The "telomere crisis model" proposed here suggests that these unique telomeric features are responsible for the progression of cancer.

PMID:
9020020
DOI:
10.1006/bbrc.1996.5928
[Indexed for MEDLINE]

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