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Z Ernahrungswiss. 1996 Sep;35(3):282-7.

[The effect of alimentary vitamin B6 supply during pregnancy and lactation on the activity of specific transaminases of lactating rats].

[Article in German]

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Institut für Ernährungsphysiologie, Technische Universität München, Freising-Weihenstephan.


Eighty female Sprague-Dawley rats weighing 257 g were fed during gravidity a semi-synthetic diet containing five vitamin-B6-treatment groups (0.6, 3, 6, 18 and 180 mg/kg diet). The daily food intake was 14 g. During the following lactation the rats of each treatment group were divided into two groups containing 3 and 6 mg vitamin B6. At the 14th day of lactation the dams were decapitated. Parameters for determination of the vitamin-B6-status were activity of AST and ALT in plasma, erythrocytes and liver. The average activity of AST in plasma was 549 U/l, in erythrocytes 1939 U/l and liver 106 U/g fresh matter (FM). The increasing vitamin-B6-supplementation during gravidity resulted in an elevated activity of AST between lowest and highest treatment group in plasma 56%, erythrocytes 44%, and in liver 43%, respectively. In response to the increasing vitamin-B6-treatment during lactation the activity of AST in plasma increased for 19%, in erythrocytes for 13%, and in liver for 24%, respectively. A low vitamin-B6-supply (0.6 mg/kg diet) during gravidity in combination with demand-oriented supply during lactation (6 mg/kg diet) initiated the highest increase of activity. A deficient vitamin-B6-supply during lactation (3 mg/kg diet) could be compensated with optimal vitamin-B6-supply during gravidity. The values of ALT-activity showed no significant differences between the graded vitamin-B6-supplements, as a result of a high coenzyme saturation.

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