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Biol Neonate. 1977;32(1-2):77-82.

Phenobarbital-induced brain growth retardation in artificially reared rat pups.

Abstract

Phenobarbital was administered daily to rat pups during the period of their brain growth spurt. A new technique for artificially rearing rat pups, using chronic intragastric feeding cannulas, was used to prevent drug-induced undernutrition. Rats, receiving neonatal phenobarbital, experienced a marked interruption of early brain growth, although their body weights reflected normal growth.

PMID:
901883
DOI:
10.1159/000240998
[Indexed for MEDLINE]

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