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Arch Dermatol Res. 1996 Dec;289(1):1-8.

Cytokines and their effects on maturation, differentiation and migration of dendritic cells.

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Department of Dermatology, University of Mainz, Germany.


In this review the role of cytokines in the maturation and migration of phenotypically and functionally diverse dendritic cell (DC) subpopulations is discussed and their role in progress of differentiation from bone marrow progenitors to lymphoid DC is described. GM-CSF is the most important cytokine for the development of functional DC and acts in concert with a varying mixture of other cytokines such as IL-4, IL-1 and TNF-alpha to direct the development of individual DC subpopulations.

[Indexed for MEDLINE]

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