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Mol Med Today. 1996 Dec;2(12):519-27.

Replicating viruses as selective cancer therapeutics.

Author information

1
Director of Pre-clinical and Clinical Research, ONYX Pharmaceuticals, Richmond, CA 94806, USA.

Abstract

Replication-competent viruses are used as selective cancer therapeutics and the mechanisms leading to tumor-specific replication and antitumoral efficacy are now becoming apparent. The specific viruses in development include tumor-targeting herpes simplex viruses, autonomous parvoviruses, Newcastle disease viruses and adenovirus. Information is also available on antiviral immunology and viral defenses against host-mediated immunity. This approach has many potential attributes, in addition to potential hurdles that must be overcome.

PMID:
9015793
DOI:
10.1016/s1357-4310(97)81456-6
[Indexed for MEDLINE]

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