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Biochem Biophys Res Commun. 1997 Jan 23;230(3):552-6.

Myosin binding subunit of smooth muscle myosin phosphatase at the cell-cell adhesion sites in MDCK cells.

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1
Laboratory of Biochemistry, Aichi Cancer Center Research Institute, Nagoya, Japan.

Abstract

We examined the intracellular localization of the myosin binding subunit (MBS) of smooth muscle myosin phosphatase. In MDCK cells in a confluent monolayer of polarized epithelial sheet, MBS was concentrated to the cell-cell adhesion sites. Double-immunofluorescence analysis with anti-MBS and anti-beta-catenin antibodies showed that MBS was mainly localized at the adherens junction. Furthermore, MBS was translocated reversibly between the cytosol and the cell-cell adhesion sites during the formation and disappearance of cell-cell contacts. These data suggest that MBS may play an important role in the regulation of the cell-cell adhesion.

PMID:
9015360
DOI:
10.1006/bbrc.1996.5986
[Indexed for MEDLINE]

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