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Receptors Channels. 1996;4(3):161-4.

Automated modelling of the transmembrane region of G-protein coupled receptor by Swiss-model.

Author information

1
BioInformatics, Glaxo Institute for Molecular Biology, Geneva, Switzerland.

Abstract

Molecular modelling of the transmembrane helices of G-protein coupled receptors is an increasingly used method to identify the possible three-dimensional environment of key residues. Thereby site-directed mutagenesis experiments, aimed at the understanding of the receptor-ligand interactions, can be designed in a rational way. The modelling methods are however not generally available to experimentalists, and often require expensive software and hardware. To overcome these limitations, we have constructed a World Wide Web server for the automated protein modelling of user-defined transmembrane helices. The service is freely available at this address: http:/(/)expasy.hcuge.ch/swissmod/SWISS-MODEL.++ +html.

PMID:
9014239
[Indexed for MEDLINE]

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