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Curr Opin Cell Biol. 1997 Feb;9(1):99-108.

Cytoskeletal and adhesion proteins as tumor suppressors.

Author information

1
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel. lgbenzev@weizmann.weizmann.ac.il

Abstract

In the past year, significant progress has been made in the attempt to understand the molecular mechanisms underlying signaling that is induced by cell-cell and cell-extracellular-matrix adhesion and that involves the cytoskeleton. In particular, molecules of the cytoplasmic plaques of cell-cell junctions have been shown to complex with transcription factors and to translocate into the nucleus. In addition, such junctional plaque proteins have been shown to act as effective suppressors of tumorigenesis.

PMID:
9013672
DOI:
10.1016/s0955-0674(97)80158-5
[Indexed for MEDLINE]

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