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Curr Opin Cell Biol. 1997 Feb;9(1):93-8.

Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression.

Author information

1
Department of Cell Biology and Anatomy, Cancer Center, University of Miami School of Medicine, PO Box 016960 (R124), Miami, FL 33101, USA. rassoian@mednet.med.miami.edu

Abstract

Several studies in the past year have shown that the cell cycle events typically attributed to a response to growth factors actually require signals provided by both growth factors and the extracellular matrix. Moreover, at least some of these matrix-based effects seem to involve matrix-dependent organization of the cytoskeleton rather than cell adhesion per se. Overall, these studies are providing new insights into the long-appreciated concepts of anchorage- and shape-dependent growth.

PMID:
9013668
DOI:
10.1016/s0955-0674(97)80157-3
[Indexed for MEDLINE]

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