Abstract
A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever. Symptoms improved after discontinuation of mesalamine. A rechallenge 3 months later caused similar pulmonary symptoms, confirming the association between the drug and the respiratory system. Mesalamine may cause hypersensitivity pneumonitis in patients with Crohn's disease.
MeSH terms
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Alveolitis, Extrinsic Allergic / chemically induced*
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Alveolitis, Extrinsic Allergic / diagnosis
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Aminosalicylic Acids / adverse effects*
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
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Drug Hypersensitivity / diagnosis
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Drug Hypersensitivity / etiology*
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Humans
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Inflammatory Bowel Diseases / drug therapy
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Male
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Mesalamine
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Middle Aged
Substances
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Aminosalicylic Acids
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Anti-Inflammatory Agents, Non-Steroidal
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Mesalamine