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Antisense Nucleic Acid Drug Dev. 1996 Winter;6(4):267-72.

Resistance of morpholino phosphorodiamidate oligomers to enzymatic degradation.

Author information

1
ANTIVIRALS, Inc., Corvallis, OR 97333, USA.

Abstract

Oligomers possessing the Morpholino phosphorodiamidate backbone were evaluated for resistance to a variety of enzymes and biologic fluids. A 25-mer was incubated with nucleases, proteases, esterases, and serum, and the reaction mixtures were directly analyzed by MALDI-TOF mass spectrometry. The 25-mer was completely resistant to 13 different hydrolases and serum and plasma. The excellent resistance of Morpholino phosphorodiamidates to enzymatic attack indicates their suitability for in vivo use.

PMID:
9012862
DOI:
10.1089/oli.1.1996.6.267
[Indexed for MEDLINE]

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