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Brain Res Mol Brain Res. 1996 Feb;36(1):174-8.

Transient expression of the basic helix-loop-helix protein NSCL-2 in the mouse cerebellum during postnatal development.

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Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins 80523, USA.


The spatio-temporal expression of the basic helix-loop-helix transcription factor NSCL-2 was analyzed in the postnatal development of the murine brain by in situ hybridization. We found that NSCL-2 is transiently expressed in the cerebellum. NSCL-2 was found exclusively in the premigratory zone of the external granule layer where postmitotic neurons undergo initial stages of neuronal differentiation. NSCL-2 expression was not detected in mature neurons. This pattern of expression suggests that NSCL-2 is critical for the onset of neuronal differentiation, but not for the maintenance of the differentiated state.

[Indexed for MEDLINE]

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