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Trends Biochem Sci. 1996 Dec;21(12):488-91.

How Ras-related proteins talk to their effectors.

Author information

1
Max-Planck-Institut für Molekulare Physiologie, Dortmund, Germany. Alfred.Wittinghofer@mpi-dortmund.mpg.de

Abstract

More and more effectors for the Ras-related protein superfamily are being discovered and it is emerging that these GTP-binding proteins interact with more than one effector to generate more than one cellular signal. Atomic details for the interaction of Rap/Ras with one of the effectors, the protein kinase c-Raf-1, have recently become available by X-ray structure analysis. The implications for the specificity of the signal transduction pathway, and how the GTP-dependent switch mechanism modulates the interaction with effectors will be discussed here, using Ras as a paradigm.

PMID:
9009833
DOI:
10.1016/s0968-0004(96)10064-5
[Indexed for MEDLINE]

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