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Trends Biochem Sci. 1996 Dec;21(12):460-6.

Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs.

Author information

1
Department of Molecular Pharmacology, Stanford University School of Medicine, CA 94305-5332, USA. ferrell@cmgm.stanford.edu

Abstract

Recent experimental work has shown that the mitogen-activated protein (MAP) kinase cascade can convert graded inputs into switch-like outputs. The cascade could therefore filter out noise (signals of insufficient magnitude or duration) and still respond decisively to supra-threshold stimuli. Here, we explore the biochemical mechanisms likely to be at the root of this behavior.

PMID:
9009826
[Indexed for MEDLINE]

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