Abstract
Recent experimental work has shown that the mitogen-activated protein (MAP) kinase cascade can convert graded inputs into switch-like outputs. The cascade could therefore filter out noise (signals of insufficient magnitude or duration) and still respond decisively to supra-threshold stimuli. Here, we explore the biochemical mechanisms likely to be at the root of this behavior.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Enzyme Inhibitors / metabolism
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Enzyme Inhibitors / pharmacokinetics*
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Enzyme Inhibitors / pharmacology
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Humans
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Models, Biological*
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Phosphorylation
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Protein Kinases / chemistry*
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Protein Kinases / drug effects
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Protein Kinases / metabolism*
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Signal Transduction*
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Xenopus
Substances
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Enzyme Inhibitors
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Protein Kinases