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Nutr Rev. 1996 Sep;54(9):290-2.

Adipocyte differentiation is regulated by a prostaglandin liganded to the nuclear peroxisome proliferator-activated receptor.

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1
Department of Nutritional Sciences, University of California, Berkeley 94720-3104, USA.

Abstract

Adipocyte differentiation and the homeostasis of fat cell number are regulated by a nuclear receptor protein, the peroxisome proliferator-activated receptor (PPAR gamma). The endogenous ligand is thought to be 15-deoxy-delta 12,14-prostaglandin J2-Thiazolidinedione, an antidiabetic drug, closely mimics the action of the prostaglandin, suggesting a regulatory role by the prostaglandin and PPAR gamma both in adipocyte differentiation and in glucose homeostasis.

PMID:
9009672
[Indexed for MEDLINE]
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