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Protein Sci. 1997 Jan;6(1):249-53.

SAM as a protein interaction domain involved in developmental regulation.

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1
EMBL, Heidelberg, Germany.

Abstract

More than 60 previously undetected SAM domain-containing proteins have been identified using profile searching methods. Among these are over 40 EPH-related receptor tyrosine kinases (RPTK), Drosophila bicaudal-C, a p53 from Loligo forbesi, and diacyglycerol-kinase isoform delta. This extended dataset suggests that SAM is an evolutionary conserved protein binding domain that is involved in the regulation of numerous developmental processes among diverse eukaryotes. A conserved tyrosine in the SAM sequences of the EPH related RPTKs is likely to mediate cell-cell initiated signal transduction via the binding of SH2 containing proteins to phosphotyrosine.

PMID:
9007998
PMCID:
PMC2143507
DOI:
10.1002/pro.5560060128
[Indexed for MEDLINE]
Free PMC Article
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