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Aust N Z J Obstet Gynaecol. 1996 Nov;36(4):487-9.

Low dose ketoconazole is an effective and a relatively safe alternative in the treatment of hirsutism.

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Reproductive Endocrinology Department, Dr Zekai Tahir Burak Women's Hospital, Ankara, Turkey.


Efficacy, clinical and hormonal effect of ketoconazole in 400 mg/day dose was tested in a prospectively-designed study. Twenty four patients with hirsutism according to the Ferriman and Gallwey score (> 8) and elevated blood androgen levels were administered 400 mg/day ketoconazole for 6 months. Basal and posttherapy early follicular phase androgens and biochemical parameters were evaluated. In 22 patients significant improvement and in 2 slight improvement was seen in subjective complaints. No side-effects were observed in these patients other than 2 cases of pruritus (transient), 2 mild gastric upset and 1 mastodynia. All patients completed the study. Low dose ketoconazole seems to be effective in the treatment of hirsutism with relatively few side-effects but still should be reserved as an alternative choice due to the potential for deleterious hepatic effects.

[Indexed for MEDLINE]

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