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Arch Ophthalmol. 1997 Jan;115(1):40-4.

The contralateral corneal endothelium in the iridocorneal endothelial syndrome.

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1
Department of Ophthalmology, Mayo Clinic, Rochester, Minn., USA.

Abstract

OBJECTIVE:

To evaluate the corneal endothelial morphometric measures of the contralateral, clinically uninvolved eye of patients with the iridocorneal endothelial (ICE) syndrome.

DESIGN:

A retrospective review of the specular microscopic photographs of the contralateral corneal endothelium of all patients with ICE syndrome seen at Mayo Clinic, Rochester, Minn.

SETTING:

Ophthalmology department, Mayo Clinic.

PARTICIPANTS:

Twenty-eight patients with unilateral ICE syndrome who had bilateral endothelial photographs (ICE group) and 28 normal, age-matched control subjects (control group).

MAIN OUTCOME MEASURES:

Percentage of hexagonal cells, coefficient of variation of cell area, and endothelial cell density.

METHODS:

For each patient and control, 100 endothelial cells were digitized from projected endothelial photomicrographs of the central corneas in the uninvolved eyes.

RESULTS:

A statistically significant decrease was noted in the mean percentage of hexagonal cells (ICE, 62%; control, 69%; P = .002), and an increase was noted in the mean coefficient of variation of cell area (ICE, 0.28; control, 0.25; P = .02) in the patients with ICE syndrome compared with normal, age-matched controls. The mean endothelial cell density did not differ significantly between the 2 groups (ICE, 2588; control, 2759; P = .10).

CONCLUSION:

Our data suggest that the clinically uninvolved, contralateral eyes in patients with ICE syndrome have subclinical endothelial abnormalities as evidenced by a relatively low percentage of hexagonal cells and a relatively high coefficient of variation of cell area.

[Indexed for MEDLINE]

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