Format

Send to

Choose Destination
J Clin Invest. 1997 Jan 15;99(2):305-14.

Quasiperiodicity and chaos in cardiac fibrillation.

Author information

1
Department of Medicine (Cardiology), University of California, Los Angeles School of Medicine, 90095, USA. alang@lifesci.ucla.edu

Abstract

In cardiac fibrillation, disorganized waves of electrical activity meander through the heart, and coherent contractile function is lost. We studied fibrillation in three stationary forms: in human chronic atrial fibrillation, in a stabilized form of canine ventricular fibrillation, and in fibrillation-like activity in thin sheets of canine and human ventricular tissue in vitro. We also created a computer model of fibrillation. In all four studies, evidence indicated that fibrillation arose through a quasiperiodic stage of period and amplitude modulation, thus exemplifying the "quasiperiodic transition to chaos" first suggested by Ruelle and Takens. This suggests that fibrillation is a form of spatio-temporal chaos, a finding that implies new therapeutic approaches.

PMID:
9005999
PMCID:
PMC507798
DOI:
10.1172/JCI119159
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Society for Clinical Investigation Icon for PubMed Central
Loading ...
Support Center