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J Clin Microbiol. 1997 Feb;35(2):479-81.

A Mycobacterium tuberculosis IS6110 preferential locus (ipl) for insertion into the genome.

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1
Medical Microbiology, Aberdeen University, Foresterhill, Aberdeen, United Kingdom.

Abstract

A 267-nucleotide Mycobacterium tuberculosis genomic sequence (ipl, the IS6110 preferential locus) which can harbor the insertion sequence IS6110 at six alternative locations has been identified in some three-quarters of the isolates tested. Only one IS6110 copy was observed at this locus in the ipl::IS6110(+)-containing isolates tested, and all insertions had the same orientation. The implications of this finding for IS6110 fingerprint typing methods is discussed in this work.

PMID:
9003621
PMCID:
PMC229605
[Indexed for MEDLINE]
Free PMC Article
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