Format

Send to

Choose Destination
J Neuroimmunol. 1997 Jan;72(1):11-9.

beta-Interferon regulates the immunomodulatory activity of neonatal rodent microglia.

Author information

1
University of Cambridge, Department of Neurology, Addenbrooke's Hospital, UK. glh20@medschl.cam.ac.uk

Abstract

beta-interferon (beta-IFN) has both pro and anti-inflammatory properties, the balance of which leads to some suppression of disease activity in multiple sclerosis patients. Here, we examine the immunomodulation of neonatal rodent microglia, the principal CNS accessory cell, by beta-IFN and consider the interaction of beta-IFN and gamma-interferon (gamma-IFN). beta-IFN and gamma-IFN inhibit microglial proliferation. beta-IFN antagonises both gamma-IFN-induced upregulation of class II expression and the ability of gamma-IFN primed cells to mount a respiratory burst. In contrast, beta-IFN upregulates microglial Fc receptor expression and augments tumour necrosis factor alpha secretion from suboptimally stimulated microglia.

PMID:
9003241
DOI:
10.1016/s0165-5728(96)00128-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center