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Am J Kidney Dis. 1997 Jan;29(1):119-24.

Membranous lupus nephritis with antineutrophil cytoplasmic antibody-associated segmental necrotizing and crescentic glomerulonephritis.

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1
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

Abstract

Focal segmental necrotizing and crescentic lupus nephritis accompanied by perinuclear antineutrophil cytoplasmic antibody (P-ANCA) seropositivity is an unusual occurrence. We report the first biopsy-documented cases of membranous lupus nephritis class V with associated "pauci-immune" segmental necrotizing glomerulonephritis and P-ANCA seropositivity. The absence of subendothelial electron-dense deposits favored a manifestation of superimposed ANCA-associated glomerulonephritis rather than class III lupus nephritis. The pathogenetic implications of this association are explored.

PMID:
9002540
DOI:
10.1016/s0272-6386(97)90018-4
[Indexed for MEDLINE]

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