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EXS. 1997;79:419-28.

Control of angiogenesis by the pericyte: molecular mechanisms and significance.

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  • 1Laboratory for Surgical Research, Children's Hospital, Boston, Massachusetts, USA.


The microvasculature consists of endothelial cells (EC) with albuminally located pericytes. A number of clinical and experimental observations suggest that pericytes contribute to the regulation of microvascular growth and function. EC and pericytes appear to have a variety of means whereby they may influence one another, including soluble growth factors, gap junctions and adhesion molecules, to name a few. Co-culture systems have provided a good deal of evidence to support the concept that these two cells interact and that these communications are central to vessel assembly, growth control and normal function.

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