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FEBS Lett. 1997 Jan 3;400(2):211-4.

Identification and expression of a variant isoform of the levocabastine-sensitive neurotensin receptor in the mouse central nervous system.

Author information

1
Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, UPR 411, Valbonne, France.

Abstract

This work describes the molecular cloning of a variant isoform of the low-affinity levocabastine-sensitive neurotensin receptor isolated from mouse brain. Although the corresponding mRNA encodes for a 282 amino acid protein unable to bind neurotensin after transient transfection in COS-7 cells, this non-functional neurotensin receptor is expressed in cerebral neocortex, cerebellum, olfactory bulb, striatum and hypothalamus with a level similar to that of the full-length low-affinity neurotensin receptor. By contrast, this receptor form is very weakly expressed in mesencephalon and absent in the pituitary, but is the major product in the spinal cord.

PMID:
9001400
DOI:
10.1016/s0014-5793(96)01391-9
[Indexed for MEDLINE]
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