Send to

Choose Destination
FEBS Lett. 1997 Jan 3;400(2):211-4.

Identification and expression of a variant isoform of the levocabastine-sensitive neurotensin receptor in the mouse central nervous system.

Author information

Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, UPR 411, Valbonne, France.


This work describes the molecular cloning of a variant isoform of the low-affinity levocabastine-sensitive neurotensin receptor isolated from mouse brain. Although the corresponding mRNA encodes for a 282 amino acid protein unable to bind neurotensin after transient transfection in COS-7 cells, this non-functional neurotensin receptor is expressed in cerebral neocortex, cerebellum, olfactory bulb, striatum and hypothalamus with a level similar to that of the full-length low-affinity neurotensin receptor. By contrast, this receptor form is very weakly expressed in mesencephalon and absent in the pituitary, but is the major product in the spinal cord.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center