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Pflugers Arch. 1997 Feb;433(4):533-5.

Developmental change in the voltage-dependence of the pacemaker current, if, in rat ventricle cells.

Author information

1
Department of Physiology and Biophysics, HSC, SUNY at Stony Brook, Stony Brook, NY, USA.

Abstract

Myocytes were isolated from newborn and adult rat ventricle. Using the whole-cell patch clamp, the two cell populations were compared for the presence of the hyperpolarization-activated pacemaker current if. As in other mammalian species, the threshold voltage in acutely dissociated adult rat myocytes was extremely negative (-113 +/- 5 mV; n=12). In contrast, threshold in newborn cells was relatively positive, regardless of whether measured in acutely dissociated (-72 +/- 2 mV; n=6) or cultured cells (-70 +/- 2 mV; n=9). Current density was not reduced in the adult. These results suggest that with development the ventricle assumes its non-pacemaker function, at least in part, by a shift of the voltage dependence of if outside the physiological range.

PMID:
9000433
[Indexed for MEDLINE]

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