Send to

Choose Destination
Pflugers Arch. 1997 Feb;433(4):533-5.

Developmental change in the voltage-dependence of the pacemaker current, if, in rat ventricle cells.

Author information

Department of Physiology and Biophysics, HSC, SUNY at Stony Brook, Stony Brook, NY, USA.


Myocytes were isolated from newborn and adult rat ventricle. Using the whole-cell patch clamp, the two cell populations were compared for the presence of the hyperpolarization-activated pacemaker current if. As in other mammalian species, the threshold voltage in acutely dissociated adult rat myocytes was extremely negative (-113 +/- 5 mV; n=12). In contrast, threshold in newborn cells was relatively positive, regardless of whether measured in acutely dissociated (-72 +/- 2 mV; n=6) or cultured cells (-70 +/- 2 mV; n=9). Current density was not reduced in the adult. These results suggest that with development the ventricle assumes its non-pacemaker function, at least in part, by a shift of the voltage dependence of if outside the physiological range.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center