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J Gen Virol. 1996 Dec;77 ( Pt 12):3063-7.

Isolation and characterization of Tula virus, a distinct serotype in the genus Hantavirus, family Bunyaviridae.

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Haartman Institute, Department of Virology, University of Helsinki, Finland. Olli.Vapalahti@Helsinki.FL


A Vero E6 cell culture isolate of Tula virus (TUL), a hantavirus first detected in European common voles (Microtus arvalis and M. rossiaemeridionalis) by RT-PCR was obtained after initial passaging of TUL-infected vole lung samples in laboratory-colonized M. arvalis. TUL was defined as a classical serotype by a cross-focus-reduction neutralization test (FRNT) and was also shown to be distinct from other hantaviruses by haemagglutination inhibition assay. The sequences of S, M and partial L genome segments of the isolate were determined: the S segment was 99.9% identical to the original rodent-derived sequence. Serological evidence for a previous TUL infection was obtained from the serum of a blood donor living near a TUL focus in Moravia, Czech Republic, showing at least a 16-fold higher FRNT titre to TUL as compared to Puumala or other hantaviruses.

[Indexed for MEDLINE]

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