Abstract
Reactions of amphotericin B, a polyenic macrolide antibiotic, with aromatic aldehydes and H3PO2 resulted in formation of its new hydrophosphoryl derivatives. Physico-chemical and biological properties of the compounds were investigated. The biological studies showed that the hydrophosphoryl derivatives of amphotericin B were low toxic and had antifungal and antiviral activities.
MeSH terms
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Amphotericin B / analogs & derivatives*
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Amphotericin B / chemical synthesis
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Amphotericin B / pharmacology
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Animals
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / toxicity
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / pharmacology
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Antifungal Agents / toxicity
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology
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Antiviral Agents / toxicity
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Lethal Dose 50
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Male
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Mice
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Microbial Sensitivity Tests
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Molecular Structure
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Phosphorylation
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Spectrophotometry
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Antiviral Agents
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Amphotericin B