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Clin Neuropathol. 1996 Jan-Feb;15(1):2-6.

Fibromuscular dysplasia of the internal carotid artery: a clinicopathological study.

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Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA.


Although angiographic changes of fibromuscular dysplasia (FMD) of the carotid artery are regularly noted, histologic confirmation is rare. We therefore reviewed all patients with a histologic diagnosis of FMD affecting the internal carotid artery who were seen at our institution over a 25-year-period. FMD of the internal carotid artery was a very rare autopsy finding and was detected in only 4 of 20,244 consecutive autopsies (0.02%). In an additional 6 patients FMD of the internal carotid artery was identified in a surgical specimen. All patients were female and their mean age was 53 years. Nine patients had the medial form of FMD and 1 the intimal form. By immunohistochemistry the lesions consist of proliferations of smooth muscle with a minor fibroblastic component. FMD was rarely limited to 1 carotid artery and multivessel involvement was present in 9 patients. In reference to this experience epidemiologic, pathologic, and etiologic features of FMD of the carotid arteries are discussed.

[Indexed for MEDLINE]

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