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Cas Lek Cesk. 1996 Oct 9;135(19):634-5.

[Control mechanisms of cell transition from the G1 phase to the S phase--the R point].

[Article in Czech]

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Danish Cancer Soc., Div. Tumor Biol., Copenhagen.


The critical moment of regulation when transition of the cell from the G1 to the S phase takes which is decisive for its division is the so-called R-point (restriction point). The disorder of molecular mechanisms controlling the passage of the cell through this site is an associated manifestation of most tumourous processes. A considerable part of this mechanism is the RB protein, binding transcription factors needed for the activation of genes effective in the S phase. Its binding capacity depends on the extent of phosphorylation and on the activity of the appropriate kinases and their inhibitors.

[Indexed for MEDLINE]

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