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Gerontology. 1997;43(1-2):143-9.

Inflammation and Alzheimer's disease: mechanisms and therapeutic strategies.

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1
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA.

Abstract

Inflammatory mechanisms in the brain may contribute to the neurodegenerative process in Alzheimer's disease. The cerebral acute-phase response mediated by inflammatory cytokines, the complement cascade, and the accumulation of activated microglial cells are appropriate targets for anti-inflammatory intervention. Pilot studies showed that tolerable doses of prednisone suppress the peripheral acute-phase response in Alzheimer's disease, and a multicenter therapeutic trial of prednisone is in progress. Two other anti-inflammatory drugs, hydroxychloroquine and colchicine, are also under investigation.

PMID:
8996836
[Indexed for MEDLINE]
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