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Gerontology. 1997;43(1-2):79-94.

Neuroautoimmunity: pathogenic implications for Alzheimer's disease.

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1
School of Medicine, University of Michigan, Ann Arbor 48109, USA.

Abstract

Immune factors such as cellular immunity, autoimmunity, and inflammation may play a pathogenic role in Alzheimer's disease (AD), a neurodegenerative disorder. Based on immunologic dysregulation in many patients, a neuroautoimmunity (NAI) model is proposed which suggested a CD8+ cell-mediated mechanism (activated cytotoxic T lymphocytes); CD4+ suppressor/inducer (2H4+) cells may also be involved. Antibrain antibodies may contribute through a cell-specific autoimmune assault leading to neurodegeneration of the AD type. Thus, a cell-mediated autoimmune response against brain antigens may explain the immune subset of AD.

PMID:
8996831
[Indexed for MEDLINE]
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