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J Urol. 1997 Feb;157(2):585-9.

Desensitization of bladder sensory fibers by intravesical capsaicin has long lasting clinical and urodynamic effects in patients with hyperactive or hypersensitive bladder dysfunction.

Author information

1
Department of Urology, Hospital S. João, Porto, Portugal.

Abstract

PURPOSE:

Capsaicin was used to treat symptomatic patients with hyperactive or hypersensitive bladders.

MATERIALS AND METHODS:

Capsaicin solution (1 mM.) was instilled into the bladder of 16 patients with spinal hyperreflexia, bladder instability or hypersensibility.

RESULTS:

Frequency decreased in 14 patients and continence was achieved in 10 of 14 incontinent cases. Mean first desire to void and maximal cystometric capacity increased significantly. These effects lasted for 6 to 12 months and were renewed following repeat treatment.

CONCLUSIONS:

Bladder afferent desensitization with capsaicin is promising in patients with motor or sensory bladder dysfunction, although initial pungency might limit its use.

PMID:
8996364
[Indexed for MEDLINE]

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