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Curr Opin Immunol. 1996 Dec;8(6):822-30.

Costimulation and autoimmunity.

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Blood Center of Southeastern Wisconsin, Milwaukee 53201-2178, USA.


The past year has seen significant advances in our understanding of the role of the B7-CD28/CTLA-4 pathway in T cell activation and self-tolerance. Recent studies have demonstrated that CTLA-4 is a critical negative regulator of T cell activation and autoreactivity, revealing a previously unsuspected means by which costimulation is involved in the maintenance and breakdown of self-tolerance. Manipulation of this costimulatory pathway in animal models of autoimmunity has shown an important role for this pathway in both the initiation and progression of autoimmune diseases.

[Indexed for MEDLINE]

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